BioVis: Bioinformatics and Computational Biology Visualization

Projects People Videos Talks Publications Bibliography


Predictive Computational Models for Orthopaedics
Image-based Measurements and Models
RuleBender: Visual Debuggers for Diagram-Based Biological Models


Md. Abedul Haque
Liz Marai
Adam Smith
Yao Sun
Ashwin Venkataraman
John Wenskovitch
Wen Xu









H. Elhalawani et al, "Normal Tissue Radiomic Feature Kinetics in Oropharygeal Cancers Treated with Image-Guided Radiation Therapy: Assessment of Parotid Glands Textural Changes on Daily Non-contrast CT", Radiology Society of North America meeting RSNA 2017, pp. 0--0, 2017. (pdf) (bibtex: al-2017-NTR).

H. Elhalawani et al, "Predicting the HPV P16 Status of Oropharyngeal Cancer Patients Using Radiomics and an Ensemble of Random Forests", Radiology Society of North America meeting RSNA 2017, pp. 0--0, 2017. (pdf) (bibtex: al-2017-PTH).
C.D. Fuller, H. Elhalawani, A.S.R. Mohamed, A. White, J. Zafereo, A. Wong, J. Berends, S. AboHashem, B. Williams, J. Aymard , A. Kanwar , S. Perni , C. Rock , L. Cooksey , S. Campbell , Y. Ding, S. La, "Permanent Repository of Matched Contrast CT Segmentation and Curated Demographic Data for the 2016 MICCAI Computational Precision Medicine (CPM) Oropharyngeal Carcinoma Radiomics Challenges", Nature Scientific Data, Vol. 0(0), pp. 0--0, 2017. (pdf) (bibtex: Fuller-2017-PRO).
Multidisciplinary Larynx Cancer Working Group, "Conditional Survival Analysis of Patients With Locally Advanced Laryngeal Cancer: Construction of a Dynamic Risk Model and Clinical Nomogram", Nature Scientific Reports, Vol. 7(0), pp. 0--0, 2017. (pdf) (bibtex: Group-2017-CSA).



A. Kanwar et al, "Contrast-enhanced CT (CE-CT) Texture Analysis Radiomic Analysis of Pretreatment Contrast-Enhanced CT Imaging Predicts Local Failure in Oropharyngeal Cancers Treated with Radiotherapy", ASTRO 2016, pp. 1--2, 2016. (pdf) (bibtex: al-2016-CEC).
A Kanwar, AS Mohamed, LE Court, L Zhang, GE Marai, G Canahuate, JS Lee, S Perni, JA Messer, BH Pham, B Youssef, D Vock, A Rao, J Kalpathy-Cramer, GB Gunn, DI Rosenthal, CD Fuller, "Development of a Predictive Quantitative Contrast Computed Tomography-Based Feature (Radiomics) Profile for Local Recurrence in Oropharyngeal Cancers", International Journal of Radiation Oncology, Biology, Physics, Vol. 96(2), pp. 0--0, Feb 2016. (pdf) (bibtex: Kanwar-2016-DOA).


J. Aerts, G.E. Marai, K. Nieselt, C. Nielsen, M. Streit, D. Weiskopf, "Highlights from the 5th Symposium on Biological Data Visualization: Part 1", BMC Bioinformatics, Vol. 16(0), pp. 1--2, 2015. (bibtex: Aerts-2015-HFT).
J. Aerts2, G.E. Marai, K. Nieselt, C. Nielsen, M. Streit, D. Weiskopf, "Highlights from the 5th Symposium on Biological Data Visualization: Part 2", BMC Proceedings, Vol. 9(0), pp. 1--2, 2015. (bibtex: Aerts2-2015-HFT).
J. Aurisano, K. Reda, A. Johnson, G.E. Marai, J. Leigh, "BactoGeNIE: A Large-Scale Comparative Genome Visualization for Big Displays", BMC Bioinformatics, Vol. 16(0), pp. 1--13, 2015. (pdf) (bibtex: Aurisano-2015-BAL).


G.E. Marai, S. O’Donoghue, C. Bartlett and J. Aerts (editors), "BMC Bioinformatics Biological Data Visualization Series", BioMed Central, Vol. 0(0), pp. 1--100, 2014. (bibtex: Marai-2014-BBB).
J. Wenskovitch, L.A. Harris, J.J. Tapia, J.R. Faeder, G.E. Marai, "MOSBIE: A Tool for Comparison and Analysis of Rule-Based Biochemical Models", BMC Bioinformatics Journal 15:316, Vol. 15(0), pp. 1--22, 2014. (pdf) (bibtex: Wenskovitch-2014-MAT).



Md. A. Haque, G. E. Marai, "A Semi-Automated Method for Subject-Specific Modeling of the Spinal Canal from Computed Tomography Images and Dynamic Radiographs", The 18th International Workshop on Vision, Modeling and Visualization, pp. 1--8, Sep 2013. (pdf) (bibtex: Haque-2013-ASA).

Md. A. Haque, G. E. Marai, "Image to Mesh: Spinal Ligament 3D Surface Models from Bone Volume Images and Dynamic Radiographs", MeshMed: Workshop on Mesh Processing in Medical Imaging, Medical Image Computing and Computer Assisted Intervention (MICCAI) 2013, pp. 1--12, Sep 2013. (pdf) (bibtex: Haque-2013-ITM).


A. M. Smith, "INTEGRATED MODELING, SIMULATION, AND VISUALIZATION FOR RULE-BASED INTRACELLULAR BIOCHEMISTRY", Master's Thesis, Vol. 0(4), pp. 0--0, Apr 2012. (pdf) (bibtex: Smith-2012-IMS).
A.M. Smith, W. Xu, Y. Sun, J.R. Faeder, G.E. Marai, "RuleBender: Integrated Modeling, Simulation and Visualization for Rule-Based Intracellular Biochemistry", BMC Journal of Bioinformatics, Vol. 13(6), pp. 1--16, Jun 2012. (pdf) (bibtex: Smith-2012-RIM).


IEEE BioVis'11 Best Paper Award
A.M. Smith, W. Xu, Y. Sun, J.R. Faeder, G.E. Marai, "RuleBender: Integrated Visualization for Biochemical Rule-Based Modeling", IEEE Visualization 2011, IEEE BioVIs: Symposium on Biological Data Visualization, pp. 1--8, Oct 2011. (pdf) (bibtex: Smith-2011-RIV).

A. Smith, W. Xu, J.R. Faeder, G.E. Marai, "Scalable Global Views for Biological Rule-Based Modeling", IEEE Visualization 2011, Information Visualization, Poster Abstracts with System Demonstration, pp. 1--2, Oct 2011. (pdf) (bibtex: Smith-2011-SGV).
W. Xu, A. Smith, J.R. Faeder, G.E. Marai, "RuleBender: A Visual Interface for Rule-Based Modeling", Bioinformatics Journal, Vol. 27(4), pp. 1721--2, Apr 2011. (pdf) (bibtex: Xu-2011-RAV).


[A.M. Smith-2010-VTF]

A.M. Smith, W. Xu, Y. Sun, J.R. Faeder, G.E. Marai, "Visual Tools for Modeling and Simulation of Cell Signaling Networks ", Carnegie Mellon University Bioimaging Informatics Symposium, pp. 1--1, Sep 2010. (pdf) (bibtex: A.M. Smith-2010-VTF).



G.E. Marai, J.J. Crisco, D.H. Laidlaw, "Development of a Kinematic 3D Carpal Model to Analyze In Vivo Soft-Tissue Interaction Across Multiple Static Postures", The 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'09), pp. 0--0, Sep 2009. (pdf) (bibtex: Marai-2009-DOA).

G.E. Marai, J.J. Crisco, D.H. Laidlaw, "Estimation of Optimal Carpal Contact in the Human Wrist from Multiple Static Articulation Postures", BMES (Biomedical Engineering Society) 2009 Annual Fall Scientific Meeting, pp. 0--0, Oct 2009. (pdf) (bibtex: Marai-2009-EOO).



G.E. Marai, J.J. Crisco, D.H. Laidlaw, "A Kinematics-Based Method for Evaluating the Stabilizing Role of Ligaments in the Carpal Joint", 16th Annual Symposium on Computational Methods in Orthopaedic Biomechanics, pp. 0--0, Mar 2008. (pdf) (bibtex: Marai-2008-AKB).


J.J. Crisco, D. Moore, G.E. Marai, D.H. Laidlaw, E. Akelman, A. C. Weiss, S.W. Wolfe, "Effects of Distal Radius Malunion on Distal Radioulnar Joint Mechanics -- An In-Vivo Study", Journal of Orthopedic Research, Vol. 25(1), pp. 547--555, Jan 2007. (pdf) (bibtex: Crisco-2007-EOD).
G.E. Marai, "Data-driven Predictive Modeling of Diarthrodial Joints", Ph.D. Dissertation, Brown University, Vol. 0(5), pp. 0--0, May 2007. (pdf) (bibtex: Marai-2007-DDP).



G.E. Marai, J.J. Crisco, D.H. Laidlaw, "A Kinematics-Based Method for Generating Cartilage Maps and Deformations in the Multi-Articulating Wrist Joint From CT Images", IEEE 2006 Conference of the Engineering in Medicine and Biology Society (EMBC'06), pp. 2079--2082, Sep 2006. (pdf) (bibtex: Marai-2006-AKB).



G. E. Marai, C. Demiralp, S. Andrews, D. H. Laidlaw, "JointViewer -- an interactive system for exploring orthopedic data", IEEE Visualization 2004 Poster Compendium, pp. 0--0, 2004. (pdf) (bibtex: Marai-2004-JAI).



J.J. Crisco, G.E. Marai, D.H. Laidlaw, D. Moore, E. Akelman, "Kinematic and mechanical changes in the distal radioulnar joint (druj) of patients with malunited distal radius fractures", 49th Annual Meeting of the Orthopaedic Research Society, pp. 0--0, 2003. (pdf) (bibtex: Crisco-2003-KAM).

G.E. Marai, D.H. Laidlaw, J.J. Coburn, M.A. Upal, J.J. Crisco, "A 3D Method for Segmenting and Registering Carpal Bones from CT Volume Images", Annual Meeting of the American Society of Biomechanics, pp. 0--0, 2003. (pdf) (bibtex: Marai-2003-A3M).
G.E. Marai, D.H. Laidlaw, C. Demiralp, S. Andrews, C.M. Grimm, J.J. Crisco, "Estimating Joint Contact Areas and Ligament Lengths from Bone Kinematics and Surfaces", IEEE Transactions on Biomedical Engineering, Vol. 51(5), pp. 790--799, May 2003. (pdf) (bibtex: Marai-2003-EJC).



G.E. Marai, D.H. Laidlaw, C. Demiralp, C. Grimm, J.J. Crisco, D. Moore, A.E. Akelman, "Contact Areas and Ligament Lengths are Abnormal in Patients with Malunited Distal Radius Fracture Despite Normal Radioulnar Kinematics", 4th World Congress Biomechanics, pp. 0--0, Aug 2002. (pdf) (bibtex: Marai-2002-CAA).


C. Demiralp, G.E. Marai, S. Andrews, D.H. Laidlaw, J.J. Crisco, C. Grimm, "Modeling and Visualization of Inter-Bone Distances in Joints", IEEE Visualization 2001, Work in Progress Proc., Vol. 0(0), pp. 0--0, 2001. (pdf) (bibtex: Demiralp-2001-MAV).