Image-based Measurements and Models

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Status: Completed

With appropriate tools, models of small structures that are currently not measurable directly can be inferred from medical image data. We introduced non-invasive methods for estimating individual-specific soft-tissue geometry solely from kinematic data and bone surfaces. The approach enhances the capabilities of radiation-based imaging: we are able to capture in vivo soft-tissue information that used to be measurable only through invasive means.


Precision Medicine and Medical Image Analysis
BioVis: Bioinformatics and Computational Biology Visualization


Liz Marai
Ashwin Venkataraman


NSF-DMS-1557559 (Collaborative Research: SMART)




BBSI: Data-driven Modeling of Joints





H. Elhalawani et al, "Normal Tissue Radiomic Feature Kinetics in Oropharygeal Cancers Treated with Image-Guided Radiation Therapy: Assessment of Parotid Glands Textural Changes on Daily Non-contrast CT", Radiology Society of North America meeting RSNA 2017, pp. 0--0, 2017. (pdf) (bibtex: al-2017-NTR).

H. Elhalawani et al, "Predicting the HPV P16 Status of Oropharyngeal Cancer Patients Using Radiomics and an Ensemble of Random Forests", Radiology Society of North America meeting RSNA 2017, pp. 0--0, 2017. (pdf) (bibtex: al-2017-PTH).
C.D. Fuller, H. Elhalawani, A.S.R. Mohamed, A. White, J. Zafereo, A. Wong, J. Berends, S. AboHashem, B. Williams, J. Aymard , A. Kanwar , S. Perni , C. Rock , L. Cooksey , S. Campbell , Y. Ding, S. La, "Permanent Repository of Matched Contrast CT Segmentation and Curated Demographic Data for the 2016 MICCAI Computational Precision Medicine (CPM) Oropharyngeal Carcinoma Radiomics Challenges", Nature Scientific Data, Vol. 0(0), pp. 0--0, 2017. (pdf) (bibtex: Fuller-2017-PRO).
Multidisciplinary Larynx Cancer Working Group, "Conditional Survival Analysis of Patients With Locally Advanced Laryngeal Cancer: Construction of a Dynamic Risk Model and Clinical Nomogram", Nature Scientific Reports, Vol. 7(0), pp. 0--0, 2017. (pdf) (bibtex: Group-2017-CSA).


A. Kanwar et al, "Contrast-enhanced CT (CE-CT) Texture Analysis Radiomic Analysis of Pretreatment Contrast-Enhanced CT Imaging Predicts Local Failure in Oropharyngeal Cancers Treated with Radiotherapy", ASTRO 2016, pp. 1--2, 2016. (pdf) (bibtex: al-2016-CEC).
A Kanwar, AS Mohamed, LE Court, L Zhang, GE Marai, G Canahuate, JS Lee, S Perni, JA Messer, BH Pham, B Youssef, D Vock, A Rao, J Kalpathy-Cramer, GB Gunn, DI Rosenthal, CD Fuller, "Development of a Predictive Quantitative Contrast Computed Tomography-Based Feature (Radiomics) Profile for Local Recurrence in Oropharyngeal Cancers", International Journal of Radiation Oncology, Biology, Physics, Vol. 96(2), pp. 0--0, Feb 2016. (pdf) (bibtex: Kanwar-2016-DOA).


Md. A. Haque, G. E. Marai, "A Semi-Automated Method for Subject-Specific Modeling of the Spinal Canal from Computed Tomography Images and Dynamic Radiographs", The 18th International Workshop on Vision, Modeling and Visualization, pp. 1--8, Sep 2013. (pdf) (bibtex: Haque-2013-ASA).

Md. A. Haque, G. E. Marai, "Image to Mesh: Spinal Ligament 3D Surface Models from Bone Volume Images and Dynamic Radiographs", MeshMed: Workshop on Mesh Processing in Medical Imaging, Medical Image Computing and Computer Assisted Intervention (MICCAI) 2013, pp. 1--12, Sep 2013. (pdf) (bibtex: Haque-2013-ITM).


G.E. Marai, J.J. Crisco, D.H. Laidlaw, "A Kinematics-Based Method for Evaluating the Stabilizing Role of Ligaments in the Carpal Joint", 16th Annual Symposium on Computational Methods in Orthopaedic Biomechanics, pp. 0--0, Mar 2008. (pdf) (bibtex: Marai-2008-AKB).


J.J. Crisco, D. Moore, G.E. Marai, D.H. Laidlaw, E. Akelman, A. C. Weiss, S.W. Wolfe, "Effects of Distal Radius Malunion on Distal Radioulnar Joint Mechanics -- An In-Vivo Study", Journal of Orthopedic Research, Vol. 25(1), pp. 547--555, Jan 2007. (pdf) (bibtex: Crisco-2007-EOD).
G.E. Marai, "Data-driven Predictive Modeling of Diarthrodial Joints", Ph.D. Dissertation, Brown University, Vol. 0(5), pp. 0--0, May 2007. (pdf) (bibtex: Marai-2007-DDP).


G.E. Marai, J.J. Crisco, D.H. Laidlaw, "A Kinematics-Based Method for Generating Cartilage Maps and Deformations in the Multi-Articulating Wrist Joint From CT Images", IEEE 2006 Conference of the Engineering in Medicine and Biology Society (EMBC'06), pp. 2079--2082, Sep 2006. (pdf) (bibtex: Marai-2006-AKB).


G. E. Marai, C. Demiralp, S. Andrews, D. H. Laidlaw, "JointViewer -- an interactive system for exploring orthopedic data", IEEE Visualization 2004 Poster Compendium, pp. 0--0, 2004. (pdf) (bibtex: Marai-2004-JAI).


G.E. Marai, D.H. Laidlaw, C. Demiralp, S. Andrews, C.M. Grimm, J.J. Crisco, "Estimating Joint Contact Areas and Ligament Lengths from Bone Kinematics and Surfaces", IEEE Transactions on Biomedical Engineering, Vol. 51(5), pp. 790--799, May 2003. (pdf) (bibtex: Marai-2003-EJC).


G.E. Marai, D.H. Laidlaw, C. Demiralp, C. Grimm, J.J. Crisco, D. Moore, A.E. Akelman, "Contact Areas and Ligament Lengths are Abnormal in Patients with Malunited Distal Radius Fracture Despite Normal Radioulnar Kinematics", 4th World Congress Biomechanics, pp. 0--0, Aug 2002. (pdf) (bibtex: Marai-2002-CAA).


C. Demiralp, G.E. Marai, S. Andrews, D.H. Laidlaw, J.J. Crisco, C. Grimm, "Modeling and Visualization of Inter-Bone Distances in Joints", IEEE Visualization 2001, Work in Progress Proc., Vol. 0(0), pp. 0--0, 2001. (pdf) (bibtex: Demiralp-2001-MAV).