When using RuleBender, please cite:
A.M. Smith, W. Xu, Y. Sun, J.R. Faeder, G.E. Marai, ‚ÄúRuleBender: Integrated Modeling, Simulation and Visualization for Rule-Based Intracellular Biochemistry‚ÄĚ, BMC Bioinformatics, 13(Suppl 8):S3: 1-24, Jun 2012.

If you are looking for MOSBIE, please go to the MOSBIE site. If using MOSBIE, please cite not only the RuleBender publication above, but also the MOSBIE one:
J. Wenskovitch, L.A. Harris, J.J. Tapia, J.R. Faeder, G.E. Marai, "MOSBIE: A Tool for Comparison and Analysis of Rule-Based Biochemical Models", BMC Bioinformatics Journal 15:316, Vol. 15(0), pp. 1--22, 2014.

Click here to get the latest release version of RuleBender
We are still ironing out the kinks in this release, so please check back soon for an updated version; you will be happy you did.


  • BioNetGen 2.2.5
  • NFSim 1.11
  • Persisted Contact Map layouts
  • Cleaner console management
  • Improved stability

This major rewrite effort presents RuleBender as an RCP application. After you download this version, please watch our tutorial on using RuleBender 2 as the workflow and a number of features have changed.